We test and review fitness products based on an independent, multi-point methodology. If you use our links to purchase something, we may earn a commission. Read our disclosures.

Biohacking sounds like some sort of wild science experiment, but it’s really quite simple: The concept involves using various “hacks” and tools to optimize your health to become the best version of yourself—physically and mentally.

Some modalities of biohacking are unproven and, frankly, quite extreme, but others are tried-and-true, with sound science to back them up—like some of the best biohacking products. Many biohacking supplements fall into the latter category as well.

While the term is very broad, biohacking supplements correct deficiencies, provide your body with essential nutrients, contribute to longevity, and/or help you reach peak performance, in the gym and outside of it.

There are lots of high-quality supplements that fit this bill, but we’ve rounded up the best biohacking supplements below. We’ve tried all of these supplements ourselves and put them through our supplement testing methodology, which involves objectively assessing their formulation, ingredients, customer service, and third-party testing. Without further ado, here are our top picks.

Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider.

Best Biohacking Supplements

Best Magnesium for Biohacking: Transparent Labs ZMO

Good for: People who are magnesium-deficient and looking for a highly absorbable form of the mineral

Best Magnesium

Transparent Labs ZMO

GGR Score: 4.2 starstarstarstarstar

Product Highlights

  • Highly bioavailable zinc and magnesium
  • Added oyster powder for better absorption 
  • May increase endurance and immunity function

Pros & Cons


  • Non-laxative form of magnesium
  • Transparent list of ingredients
  • No artificial sweeteners, colors, or preservatives
  • Effective sleep aid


  • Expensive
  • Doesn't include vitamin B6

Bottom Line

Transparent Labs ZMO supplement provides clinically effective doses of zinc, magnesium, and oyster meat extract.

A big part of biohacking is making sure that you have optimal nutrition status. That means covering all the vitamin and mineral basics. 

Magnesium is one of those essential minerals that’s involved in approximately 80% of your metabolic functions1. It plays a role in everything from blood sugar balancing to weight loss. Because magnesium deficiency is hard to diagnose, it’s difficult to say exactly how many people are deficient, but currently it’s estimated that 45% of Americans have a deficiency, while 60% don’t get the amount they need daily.

The Transparent Labs ZMO is one of the best magnesium supplements because it combines magnesium glycinate (one of the most absorbable forms with fewer side effects) with zinc picolinate and oyster meat powder—a natural and highly bioavailable form of several essential minerals like magnesium, calcium, zinc, iron, potassium, and sodium. This formulation earns Transparent Labs ZMO a 5 out of 5 rating. 

Transparent Labs Zmo Zma

One thing to note is that the oyster meat powder does give a slight seafood/fishy taste and smell to the capsules, according to our tester, former GGR senior staff writer Amanda Capritto, CPT, CES, CNC, CF-L1. “It’s ignorable, but present,” she says. We rated taste a 4 out of 5 and swallowability a 4 out of 5 as well, since Amanda noted having to take two capsules for one serving is not the ideal.  

In addition to using clinically effective ingredients, Transparent Labs also prioritizes quality and testing. This supplement doesn’t contain any unnecessary additives or fillers, and all of the brand’s products are third-party tested. To take it a step further, Transparent Labs also makes certificates of analysis available on their website, which provides an added level of transparency that we can stand behind and earns this supplement a 5 out of 5 for third-party testing. 

Price per serving$0.97
Key ingredientsMagnesium glycinate, zinc picolinate, oyster meat powder
Third-party tested?Yes

Best Protein Powder for Biohacking: Legion Whey+

Good for: Anyone who needs an easy, bioavailable way to meet their protein requirements (a.k.a. almost everyone)

Best Protein Powder

Legion Whey+

GGR Score: 4 starstarstarstarstar

Product Highlights

  • Sourced from small dairy farms in Ireland
  • Over 5 g of BCAAs per serving
  • Non-GMO and animal welfare approved
  • Third-party tested for banned substances

Pros & Cons


  • Low in carbs and fat
  • Natural ingredients
  • Money-back guarantee
  • Made with ethically-sourced milk
  • Lots of flavor options


  • Comparably high cost per serving
  • May be clumpy when mixed
  • Some flavors have mixed reviews

Bottom Line

Legion Whey+ is a clean, sustainable protein powder that also is macro-friendly and a great option for anyone looking for a clean protein supplement. Many of our testers have brought this with their own money because they love the taste and easy mixability.

Getting the optimal amount of protein is a foundational aspect of biohacking. And of course, that protein has to be high-quality. While experienced biohackers would recommend getting as much protein as possible from nutrient-dense foods, like grass-fed meat, a clean protein powder like Legion Whey+ can help you fill the gaps. 

This protein powder has 22 to 24 grams of protein per scoop (depending on which flavor you get) with no artificial ingredients—artificial sweeteners, flavors, and colors are a no-no when you’re biohacking. And because it’s whey, it contains all the essential amino acids, including 5.6 grams of BCAAS to help support muscle recovery2. Whey is also highly bioavailable, so your muscles can use it effectively. Because of all of these factors, Legion Whey+ gets a 5 out of 5 for formulation. 

legion whey protein bag bottle

Additionally, Legion supplements are third-party tested for heavy metals, toxins, and banned substances, so if you’re a professional athlete, this is a safe choice for you. Again, 5 out of 5 here for third-party testing. 

Our GGR tester Anthony O’Reilly, CPT, CNC has tried several flavors of Legion Whey+ and Cinnamon Cereal is his favorite. “It tastes like the milk from the beginning of a bowl of Cinnamon Toast Crunch, before it’s really soaked in yet,” says Anthony, who rates the taste a 4.5 out of 5. 

Overall, Legion Whey+ is a clean protein powder with a macronutrient breakdown that can work well for all types of diets. Read our Legion whey protein review for more information.

Price per serving$2.00
Key ingredientsNon-GMO whey protein isolate, natural flavors, salt, stevia
Third-party tested?Yes

Best Vitamin D for Biohacking: Athletic Greens D3+K2

Good for: People who are deficient in vitamin D and/or live in the northeast and don’t get year-round sunlight

Best Vitamin D

Athletic Greens Vitamin D3 + K2

GGR Score: 4.45 starstarstarstarstar

Product Highlights

  • 2 drops provide 1,000 IU of vitamin D3 and 200 µg of vitamin K2
  • Each bottle contains 600 servings, so it will last a while
  • MCT coconut oil base to enhance absorption and natural vitamin E to preserve freshness
  • Formulated to support vascular, respiratory, nerve, muscular, and immune health
  • Reported benefits also include a positive mood

Pros & Cons


  • Unflavored
  • 1 bottle will last a long time
  • Provides both vitamin D3 and K2
  • Reportedly very effective
  • Non-GMO, no soy, allergen-free


  • Dropper may make measuring dosage tricky

Bottom Line

If you are looking for an easy way to boost levels of vitamin D3 and K2, Athletic Greens’ Vitamin D3 + K2 liquid is a flavorless supplement that can easily be put in any beverage.

Like magnesium, vitamin D is another essential nutrient that has a foundational role in your health. While technically a vitamin, vitamin D acts more like a multi-functional hormone3 that plays a role in your immune, cardiovascular, and endocrine systems, plus it’s been connected to mood and pain. 

And, also like magnesium, there’s a high prevalence of deficiency4 worldwide (and it’s hard to get enough vitamin D from dietary sources alone). So before you move into other biohacking products, like saunas and cold plunges, you want to make sure that your vitamin D status is optimal. 

We have a whole roundup of the best vitamin D supplements, but we like this liquid vitamin D from Athletic Greens because it’s easy to take—you can just drop it under your tongue—and it contains vitamin K, which helps your body absorb and use vitamin D effectively. Additionally, the vitamin D is in the form D3, which leads to a greater increase in blood levels5 than other forms, namely D2. In other words, if you’re deficient, vitamin D3 can get your levels up faster.

An image of Athletic Greens Vitamin D3 K2

Because of its 1,000 IU dose of vitamin D3 and 200 micrograms of vitamins K, we rate this a 5 out of 5 for formulation. 

Our tester, GGR senior staff writer and expert product tester Lauren Strong, says the supplement is a bit viscous like olive oil but tastes like coconut oil, earning it a 5 out of 5 for swallowability and a 4 out of 5 for taste. You get 1,000 IU from just two drops (that’s drops, not dropperfuls), so you don’t have to drink a bunch of a liquid. A side note—it says on the bottle that there are 600 servings inside, but Lauren disagrees. “My husband ran through this bottle in just a few months—he may have been using a bit more than recommended, but that still doesn’t quite add up!”

This vitamin D is non-GMO and allergen-free, and Athletic Greens gets their supplements third-party tested so you’re getting what they say you are.

Price per serving$0.07
Key ingredientsVitamin D3, vitamin K2, MCT oil
Third-party tested?Yes

Best Probiotic for Biohacking: Ritual Synbiotic+

Good for: Those who need gut support and want an easy way to take both probiotics and prebiotics

Best Probiotic

Ritual Synbiotic+

GGR Score: 4.3 starstarstarstarstar

Product Highlights

  • Filled with prebiotics, probiotics, and postbiotics
  • Clinically studied 
  • Supports gut barrier function
  • Delayed-release capsule designed so bacteria reaches the colon

Pros & Cons


  • Traceable ingredients
  • Supports gut lining and gut barrier function
  • Vegan
  • Non-GMO
  • Delayed-release capsule


  • Expensive
  • Automatically signs you up for subscription
  • There can be uncomfortable side effects at first

Bottom Line

The Ritual Synbiotic+ is a clinically backed probiotic with clean, traceable ingredients designed to support overall digestive health.

Any good biohacking regimen includes a focus on your gut health. While optimizing your gut health takes a multifaceted approach, a high-quality probiotic can do wonders for your digestion and overall health.

Ritual’s Synbiotic+ is a step above, and one of the best probiotic supplements. It has 11 billion CFU (a highly potent dose) of Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis, two bacteria that have proven benefits. We rate Synbiotic+ a 5 out of 5 for formulation. 

Lactobacillus rhamnosus has been shown to improve digestive diseases, alleviate allergies, contribute to cardiovascular health6, and support the immune system7, among other things. Bifidobacterium animalis ssp. lactis has been shown to help with metabolic health and weight management8.

In addition to probiotics, Synbiotic+ contains a prebiotic cocktail. It has four different types of prebiotics that feed the probiotics to help them grow and thrive. It also includes a patented fatty acid called Tributyrin that helps your body absorb the supplement—probiotics are best taken with fats9 for optimal survival. Essentially, everything you need for optimal absorption is included in the capsule, so you don’t have to worry about timing or complementary supplements.

A hand holding Ritual Synbiotic pills next to the bottle.

A fun bonus is that the capsule is mint-flavored. “It’s actually quite refreshing,” says GGR head of content and one of our expert product testers Nicole Davis. “I also think the capsules just look cool!” We rate both taste and swallowability a 5 out of 5. 

Ritual also opts into third-party testing, plus they closely trace the manufacturing process from raw ingredients to finished products to ensure purity, strength, and composition, earning Synbiotic+ a 5 out of 5 in transparency and third-party testing. 

One negative callout is that this product is expensive at $1.80 per serving, which is significantly higher than the average probiotic on the market. It is high-quality, so if you can swing it in your budget, the value is there. 

Price per serving$1.80
Key ingredientsLactobacillus rhamnosus, Bifidobacterium animalis ssp. lactis, PreforPro (prebiotic blend), Tributyrin
Third-party tested?Yes

Best Pre-Workout for Biohacking: Onnit Alpha Brain

Good for: Gym-goers who want to enhance athletic performance, focus, and mental clarity

Best Pre-Workout

Onnit Alpha BRAIN Pre-Workout

Product Highlights

  • 200 mg of caffeine
  • Includes beta alanine and L-citrulline
  • Priced around $3/serving; subscribe-and-save option available
  • 2 flavors currently available

Pros & Cons


  • 200 mg of caffeine
  • Tiger's Blood flavor tastes great
  • Includes 225 mg of ashwagandha extract
  • Contains beta alanine and L-citrulline
  • Subscribe-and-save option is available


  • Only 2 flavors available, and Yuzu Peach isn't popular among our product testers
  • $3/serving is expensive
  • Key ingredients like citrulline and beta-alanine are under-dosed

Bottom Line

Onnit's Alpha BRAIN Pre-Workout is a unique blend of ingredients that our testers enjoyed for workouts where they wanted to be focused and energized. It only comes in two flavors; the Tiger's Blood flavor is our preferred choice.

Onnit’s Alpha Brain is one of the best pre-workouts for biohackers who want to improve energy production and cognitive function, in addition to boosting physical performance.

It has all the usual pre-workout suspects, like caffeine, beta-alanine, L-citrulline, and theobromine, which can promote muscle endurance and power and reduce the perception of fatigue. But it also includes some novel ingredients, like NooGandha, a patented form of ashwagandha that’s been shown to improve athletic performance10 and aid in optimal brain health.

RELATED: Best Ashwagandha Supplements

Man testing Onnit Alpha BRAIN pre-workout

Nootropics, which are supplements that are said to improve brain function, and adaptogens, substances that help your body respond and adapt to mental and physical stress, are huge for biohacking—and ashwagandha falls into both categories.

Essentially, Onnit Alpha Brain can contribute to both peak mental and physical performance—a biohacker’s main goal.

Multiple people on the GGR team, including GGR senior director of content and certified personal trainer Kate Meier, tried this and they all agreed that they had better focus and clarity during their workouts, and got a good pump, too. It doesn’t make you feel jacked up, but gives you steady energy levels where you feel present and ready to work.

At about $3.00 per serving, the price is pretty steep compared to other pre-workouts, but in our opinion, this is more of a combination supplement since you’re getting the mental health and stress-relieving benefits, too.

Read our Onnit Alpha Brain pre-workout review for more details.

Price per serving$3.00
Key ingredientsBeta alanine, l-citrulline, African oil palm extract, ashwagandha extract, caffeine anhydrous, Alpha-GPC, theobromine, Dynamine
Third-party tested?Yes

Best Multivitamin for Biohacking: Rootine Smart Multivitamin

Good for: People who don’t mind paying more for a targeted multivitamin

Best Multivitamin

Rootine Smart Multivitamins

GGR Score: 3.62 starstarstarstarstar

Product Highlights

  • Individualized multivitamin supplement
  • Formulated using results from blood tests
  • Tests available for blood vitamin content, mineral content, hormones, and DNA
  • Can use third-party DNA test results

Pros & Cons


  • Personalized based on blood test results
  • Slow-release microbeads
  • Blood vitamin, mineral, and hormone tests available
  • Can upload third-party DNA test results


  • No robust evidence to back up DNA-based nutrition
  • Expensive, starting at $94/month
  • Subscription required

Bottom Line

Rootine Smart Multivitamins are personalized vitamin and mineral supplements based on your individual nutritional needs. Rootine uses tests for blood vitamin content, blood mineral content, some hormones, and DNA to determine your vitamin formula.

A multivitamin is an easy way to supplement an otherwise healthy diet, i.e. no single supplement can give you everything you need, but it can fill in the gaps to make sure you have most of your bases covered. Rootine Smart Vitamins take things a step further.

Instead of sending out the same generic supplements to everyone, Rootine takes results from at-home DNA tests and blood work to create supplements that are personalized for you; the company identifies your specific nutrient gaps/needs, and then formulates a supplement with up to 20 different nutrients that’s specifically aimed at normalizing those levels.

RELATED: Best Multivitamins for Men

There are two important things to note here. First, this is an investment. The multivitamin itself costs $94 per month, but you’ll also have to pay for the initial DNA and blood tests, which costs about $200 to $500 each depending on which ones you choose. Second, the blood test is DIY, so you’ll have to be okay with pricking your finger or getting someone else to do it for you.

Ultimately, we think the personalization (and the short-lived pain) is worth it since you know these are exactly the nutrients you need, and optimizing your nutrient levels is one of the foundations of biohacking. 

GGR performance editor and CPT Anthony O’Reilly tested the service and sent in a blood sample to get started. Rootine responded that they needed more blood to get an accurate assessment, which Anthony said actually impressed him—a lesser company may have just taken the money and gone with it. He’s still in the process of getting his final results, however you can read our full Rootine vitamins review if you want to know more.

Price per serving$3.13
Key ingredientsVaries
Third-party tested?In-house third-party testing; cGMP-certified

Best Fatty Acid for Biohacking: Fatty15

Good for: Anyone who doesn’t eat dairy fat and/or ruminant meat

Best Fatty Acid


GGR Score: 4.2 starstarstarstarstar

Product Highlights

  • C15:0 saturated essential fatty acid supplement
  • Patented form is called FA15 powder
  • 100 mg in one capsule
  • Can potentially lower the risk of inflammation and chronic diseases over time

Pros & Cons


  • Research-backed dose of C15:0
  • Easy-to-swallow pill
  • Can potentially lower the risk of chronic diseases like type 2 diabetes and heart disease


  • Expensive
  • Research on long-term effects not yet available

Bottom Line

Fatty15 is a one-of-a-kind fatty acid supplement that has promise to improve overall health. More clinical trials need to be done to understand its long-term effects.

When you hear the term “fatty acid” you probably think of the omega-3 fatty acids you can get through the best fish oil supplement. But there’s one fatty acid you don’t often hear about, and that’s pentadecanoic acid, or C15.

Unlike omega-3s, C15 is a saturated fatty acid that’s found in small amounts in dairy fat (like butter) and ruminant meat11 (game meat like cows, deer, and elk) and some types of plants and fish. Despite being saturated, this fatty acid has been connected to a number of health benefits, like long-term heart health and metabolic, immune, and liver health12. In short, C15 is believed to combat cellular aging and enhance longevity, and that’s why biohackers love it.

An image of a woman filling a Fatty15 bottle

This Fatty15 supplement contains 100 milligrams of pentadecanoic acid, which is the research-backed dosage based on the studies that are available. During testing, GGR senior director of content Kate Meier gave this supplement a 5 out of 5 for formulation because it combines this clinically proven dose with a vegetable capsule, and that’s it. It’s also easy to swallow, earning it a 5 out of 5 in that category as well. 

Additionally, Fatty15 undergoes third-party testing to ensure that it has a minimum purity level of 99 percent.

If you want to know about this supplement and what it can do for you, check out our full Fatty15 review.

Price per serving$1.26 to $1.67, depending on subscription
Key ingredientsPentadecanoic acid (C15)
Third-party tested?Yes

Best Collagen for Biohacking: Bulletproof Collagen Peptides

Good for: People who want to support their heart, bowel, and joint health

Best Collagen

Bulletproof Collagen Peptides

GGR Score: 3.96 starstarstarstarstar

Product Highlights

  • Hydrolyzed collagen protein 
  • 18 g of protein per serving
  • 20 g of amino acids
  • Science-backed doses of collagen types I and III
  • Promote joint flexibility and skin elasticity
  • Supports bone strength and skin hydration
  • Ethically sourced
  • Available in unflavored, vanilla, and chocolate

Pros & Cons


  • Mix with hot or cold drinks
  • Mixes well
  • Convenient
  • Science-backed doses


  • Unflavored option may leave an aftertaste

Bottom Line

Bulletproof’s Collagen Peptides powder is an effective and easy way to add high-quality collagen type I and III into your diet.

No biohacking supplement list would be complete without an appearance from Bulletproof, a brand that was launched by Dave Asprey, who is often called the “father of biohacking.” While Asprey has since parted ways with Bulletproof, it still remains one of the most popular brands for biohacking supplements. The benefits of collagen protein powder are numerous, and collagen is revered by biohackers because it’s said to help stave off biological aging13.

RELATED: Bulletproof Coupon Code

We like the Bulletproof Collagen Peptides specifically because it combines two types of collagen—type I and type III—that’s sourced from grass-fed cows. Type I collagen is the most abundant in the human body and is highly biocompatible14, which means your body can actually use it. Type III collagen is a major component of your blood vessels and bowel lining15, so it can contribute to heart health and digestive function. While we would’ve liked to see Type II collagen in this formulation as well, it’s still pretty solid and earns a 3.5 out of 5 in the category. 

An image of Bulletproof collagen peptides being scooped

Each serving contains 20 grams of hydrolyzed collagen and 18 grams of total protein. (Heads up: This isn’t a complete protein like whey though, so it doesn’t take the place of it.) These collagen peptides are also enzymatically processed (a.k.a. they’re broken down by enzymes instead of chemicals), which helps keep the collagen intact and the supplement pure. This also makes it dissolve more easily.

During testing, GGR senior director of content Kate Meier found it easily incorporated into coffee, smoothies, and other recipes like baked goods and soups, rating it a 5 out of 5 for both taste and texture. (You can find other great-tasting collagens in our roundup of the best collagen supplements as well.)

Additionally, Bulletproof does both internal and external testing to ensure that their products are held to the highest standards. They have an internal risk assessment for all ingredients, and opt into third-party testing to double-check product safety and quality.

Price per serving$1.76
Key ingredientsHydrolyzed collagen
Third-party tested?Yes

Best Greens Powder for Biohacking: Nested Naturals Super Greens

Good for: Those who fall short of their daily veggie needs

Best Greens Powder

Nested Naturals Super Greens Original

Product Highlights

  • Contains over 20 whole foods, probiotics, fiber, and enzymes
  • 100% organic, non-GMO, and vegan
  • One scoop contains 667 milligrams of spirulina, 400 milligrams of chlorella, and 1.67 billion CFU of probiotics
  • Third party-tested and approved
  • Lifetime money-back guarantee

Pros & Cons


  • Non-GMO, Vegan, 100% organic
  • Available in chocolate flavor
  • Contains prebiotic inulin to help feed healthy bacteria in the gut
  • Over 20 whole foods included
  • Many reviews report noticeable differences in energy, mood, and digestion


  • May be too strong for some and irritate the stomach
  • Taste is not great but, as a powder made primarily with vegetables, that is not surprising

Bottom Line

While the taste may not suit everyone, Super Greens effectively provides users with a potent dosage of phytonutrients, micronutrients, probiotics, fiber, and enzymes.

While they don’t take the place of vegetables, the best greens powders are a good way to sneak in a ton of beneficial nutrients and ingredients. This product category has absolutely boomed over the past few years, and as a result, is also filled with sub-par options with false claims at best and contaminated products at worst.

We like the Super Greens from Nested Naturals because it’s USDA-certified organic and third-party lab tested. This is double peace of mind that the manufacturing process is regulated so you’re getting what the label says.

Person Holding Shaker Bottle With Nested Naturals Super Greens

As far as ingredients go, there are more than two dozen superfoods separated into five distinct blends: an alkalizing blend, fiber blend, antioxidant blend, probiotic blend, and enzyme blend. These are proprietary blends, however, which we don’t love. That being said, all these ingredients make the Super Greens good for gut health and a decent source (providing 10% or more of the daily value of) iron, vitamin C, vitamin K, vitamin B12, and iodine. Nested Naturals Super Greens get an average score of 3 out of 5 for formulation. 

And the taste isn’t bad either. While it’s not the most delicious greens powder we’ve tried, Frieda Johnson, NASM-CNC, ISSA-SET, GGR editor and product tester, says that it tastes fine. “It tastes like a lot of greens powders I’ve tried—mildy like the color green,” she says. “Or what I imagine a cow thinks grass tastes like.” We rated the taste a 3 out of 5. 

Solubility gets a 5 out of 5 though, as it dissolves well and there’s no graininess that you can get with other greens powders.

Read our full Nested Super Greens review for more information.

Price per serving$1.07
Key ingredientsBarley grass powder, alfalfa grass powder, wheatgrass powder, spirulina, chlorella, sea kelp, spinach powder, broccoli powder, parsley powder, collard green powder, apple powder, rice bran powder, Jerusalem artichoke inulin, beetroot powder, acerola extract powder, eleuthero powder, echinacea powder, acai juice powder, green tea extract powder, milk thistle powder, ginkgo leaf extract powder, luo han guo extract, raspberry powder, blueberry powder, carrot powder, Lactobacillus gasseri, Bifidobacterium bifidum, Bifidobacterium longum, amylase, protease, lactase, lipase, cellulase
Third-party tested?Yes

Other Biohacking Supplements We Researched

While these are our favorite biohacking supplements, there really are so many to choose from. And just because they didn’t make our list doesn’t mean they’re not great. Here are some others we considered, but didn’t crown as winners for various reasons, which are outlined below.

  • AG1: Athletic Greens’ AG1 is all over social media, and it really is an impressive supplement. Ultimately, we didn’t name it one of the best because it’s much more expensive than comparable greens powders and not everyone needs the super-charged doses. Read our full Athletic Greens review for all the info.
  • Pure Encapsulations Vitamin D3 Liquid: This is one of our favorite vitamin D supplements, but it’s missing vitamin K. When you take high doses of vitamin D, you need vitamin K to absorb and use it. While you can take them separately (or get adequate amounts in your diet), it’s just convenient to take a supplement that has them both.
  • Transparent Labs Probiotic: This is an ultra-concentrated probiotic that has 100 billion CFU of beneficial bacteria. It does have some prebiotics too, but not as many as the Synbiotic+ from Ritual.
  • Transparent Labs 100% Grass-Fed Whey Protein Isolate: While we picked the Legion Whey+ as our top whey protein choice for biohacking, you really can’t go wrong with this one either. It’s clean, lean, and comes from grass-fed cows.
  • LifeForce Magnesium: This is a high-dose magnesium supplement with several different types of the mineral. It’s a great option for those with a confirmed magnesium deficiency, but may not be needed for most.
  • Bulletproof CoQ10 Energy: Coenzyme Q10 (CoQ10) is an antioxidant that can provide cellular energy for your mitochondria and improve focus. It’s also been shown to reduce blood pressure16 and improve blood flow17. If you want to take it independently, you can do so, but you can also get similar benefits from a good pre-workout.
  • KOS A Whole Latte Gold: This superfood blend combines turmeric, ginger, cinnamon, lion’s mane mushroom, cordyceps, and red reishi. The curcumin from the turmeric can help combat inflammation, while the medicinal mushrooms can improve mood18 and make you more resilient to stress. Because it’s a drink, it’s not as quick or convenient as capsules, but it can still be beneficial to your well-being if you want to take it.

How We Picked and Tested the Best Biohacking Supplements

“Biohacking supplements” is a broad category. It can include everything from essential vitamins and minerals to nootropics like ashwagandha and L-carnitine. When picking the best biohacking supplements, we wanted to cover all the bases. That’s why we included a broad range of supplement types. 

You don’t necessarily need to take all the supplements on this list, but you can pick and choose what you need based on your own health status and biology—which is essentially the goal of biohacking.

A woman is shown drinking from a shaker cup.

Once we decided the types of supplements we wanted to include, we moved on to specifics. Most of the brands are our tried-and-true favorites that we have a lot of experience with. We’ve personally tried all of the supplements on this list. 

We put each supplement that we tested through a rigorous supplement testing methodology where we rated each on scale of 1 to 5 for multiple factors, including:

  • Taste
  • Solubility and texture
  • Formulation
  • Ingredients
  • Price
  • Third-party testing

At the end of our testing and extensive research, we only chose supplements that we would personally recommend and/or take ourselves.

Benefits of Biohacking Supplements

The ultimate goal of biohacking is to optimize your health, and supplements can make it easier to do that. While each specific supplement provides its own health benefit, here are some general benefits of biohacking supplements:

  • They make it easier to close nutritional gaps.
  • They provide nutrients you may not get in adequate amounts from food.
  • They can help you get better sleep.
  • They can support your immune system. 
  • They may enhance energy production.
  • They can improve your mood and brain health.
  • They can help you reach your body composition goals, whether that’s weight loss or muscle growth.
  • They can enhance focus and mental acuity.
  • They contribute to longevity and fight biological aging.
woman doing hip stretch

It’s worth reiterating that supplements don’t take the place of sustained lifestyle changes, though. In addition to taking supplements, you’ll also want to eat nutritious foods, get plenty of (quality) sleep, exercise regularly, and find ways to manage your stress (journaling and meditation are great options)—all foundational aspects of biohacking.

Dosing and Interactions 

When taking any supplements, you want to make sure you stick to recommended doses. More isn’t always better. 

Because each of the supplements on this list is different, there isn’t a blanket recommendation we can make here. It’s always best to work closely with healthcare professionals and/or a qualified nutritionist to figure out the right dose for you.

Also, make sure you’re being transparent about all the supplements you’re taking. Some can interact with each other and may be contraindicated for certain health conditions. 

Third-Party Testing

Third-party testing is crucial when it comes to biohacking supplements, or any supplements for that matter. Because the FDA doesn’t regulate supplements, it can be the Wild Wild West out there. 

Companies can make unsubstantiated claims about their products, or worse, sell contaminated products that can be harmful to your health. Since biohacking is all about optimizing your health, you don’t want to be taking a supplement that you think is doing good when it’s really setting you back. 

Look for supplement brands that opt into third-party testing—this ensures that the supplement actually contains what the manufacturer says it does, and that it’s pure without any contaminants. If you’re a competitive athlete, you also want to make sure they test for banned substances as part of that process.

Biohacking Supplements: FAQs

What are biohacking supplements?

On a basic level, biohacking supplements are those that help support and enhance physical and mental performance. They don’t take the place of other biohacks and lifestyle changes, like optimizing your sleep and mindfulness exercises, but they can help you get nutrients that you may be missing from your diet.

Does biohacking really work?

In short: Yes, biohacking really works, but it is a spectrum. Biohacks can range from improving your nutrition and getting better sleep (two things that are proven to make you feel better) to potentially dangerous interventions like gene editing. 

Some biohacks, like fasting and cold plunging, do work, but they can be detrimental to your health if you overdo it, or have a really stressed nervous system to start with. If you’re new to biohacking, ease into it by trying a couple things to see how you feel—and always listen to your body. 

How do you start biohacking your body?

It’s best to ease your way into biohacking. There’s so much information out there that it can get overwhelming really quickly, and we promise it’s not as complicated as it sounds. 

We recommend starting with the basics: eating a nutritious diet (many biohackers opt for primal or paleo menu), getting outside (and taking deep, belly breaths while you’re out there) for at least 10 minutes per day, and meditating/keeping a daily gratitude journal. From there, you can layer on the next steps, like biohacking supplements, intermittent fasting (if that’s your jam), cold plunging, and fitness and sleep trackers.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.


1. Workinger, JL, Doyle, RP, Bortz, J. Challenges in the Diagnosis of Magnesium Status. Nutrients. 2018;10(9):1202. doi:10.3390/nu10091202

2. Arroyo-Cerezo, A, Cerrillo, I, Ortega, Á, Fernández-Pachón MS. Intake of branched chain amino acids favors post-exercise muscle recovery and may improve muscle function: optimal dosage regimens and consumption conditions. J Sports Med Phys Fitness. 2021;61(11):1478-1489. doi:10.23736/S0022-4707.21.11843-2

3. Ellison, DL, Moran, HR. Vitamin D: Vitamin or Hormone?. Nurs Clin North Am. 2021;56(1):47-57. doi:10.1016/j.cnur.2020.10.004

4. Cui, A, Zhang, T, Xiao, P, Fan, Z, Wang, H, Zhuang, Y. Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants. Front Nutr. 2023;10:1070808. doi:10.3389/fnut.2023.1070808

5. van den Heuvel, EG, Lips, P, Schoonmade, LJ, Lanham-New, SA, van Schoor, NM. Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis. Adv Nutr. 2024;15(1):100133. doi:10.1016/j.advnut.2023.09.016

6. Capurso, L. Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol. 2019;53 Suppl 1:S1-S41. doi:10.1097/MCG.0000000000001170

7. Fong, FLY, Kirjavainen, PV, El-Nezami, H. Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors. Sci Rep. 2016;6:22845. doi:10.1038/srep22845

8. Uusitupa, HM, Rasinkangas, P, Lehtinen, MJ, et al. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020;12(4):892. doi:10.3390/nu12040892

9. Tompkins, TA, Mainville, I, Arcand, Y. The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract. Benef Microbes. 2011;2(4):295-303. doi:10.3920/BM2011.0022

10. Bonilla, DA, Moreno, Y, Gho, C, Petro, JL, Odriozola-Martínez, A, Kreider, RB. Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. J Funct Morphol Kinesiol. 2021;6(1):20. doi:10.3390/jfmk6010020

11. Venn-Watson, SK, Butterworth, CN. Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems. PLoS One. 2022;17(5):e0268778. doi:10.1371/journal.pone.0268778

12. Venn-Watson, S, Schork, NJ. Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients. 2023;15(21):4607. doi:10.3390/nu15214607

13. Wang, H. A Review of the Effects of Collagen Treatment in Clinical Studies. Polymers (Basel). 2021;13(22):3868. doi:10.3390/polym13223868

14. Naomi, R, Ridzuan, PM, Bahari, H. Current Insights into Collagen Type I. Polymers (Basel). 2021;13(16):2642. doi:10.3390/polym13162642

15. Kuivaniemi, H, Tromp, G. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene. 2019;707:151-171. doi:10.1016/j.gene.2019.05.003

16. Zhao, D, Liang, Y, Dai, S, et al. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2022;13(6):2180-2194. doi:10.1093/advances/nmac100

17. Sood, B, Patel, P, Keenaghan, M. Coenzyme Q10. In: StatPearls. Treasure Island (FL): StatPearls Publishing; January 30, 2024.

18. Docherty, S, Doughty, FL, Smith, EF. The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023;15(22):4842. doi:10.3390/nu15224842

Further reading

Ki-RO Core Trainer Harness In-Depth Review Cover Image
Ki-RO Core Trainer Harness In-Depth Review

The Ki-RO Core Traineris an innovative training harness designed to provide resistance from pretty much any direction you can think of. With all its adjustments, this harness truly feels custom-built for you. Read more

Ladder App Review (2024): Get Stronger For Less Cover Image
Ladder App Review (2024): Get Stronger For Less

A strength training app focused on progressive overload? Sign us up! Read more in our Ladder app review. Read more

Viking Press: Develop Scandinavian Strength  With This Overhead Press Variation Cover Image
Viking Press: Develop Scandinavian Strength With This Overhead Press Variation

If you're looking to enhance your pressing strength, the Viking Press could be your ticket to Valhalla. Check out our expert guide from a strength coach. Read more

Best Exercise Bikes Under $500 to Cycle in Style and on a Budget Cover Image
Best Exercise Bikes Under $500 to Cycle in Style and on a Budget

Inflation might work hard but we worked harder to find you the best exercise bikes under $500. Read more