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Isopure Whey Protein Isolate is currently one of the most popular protein powders on Amazon, racking up almost 10,000 (mostly positive) reviews. Reviewers rave about its solubility and taste (or lack thereof if you get unflavored), and some even call it the best protein powder they’ve ever had. 

With that kind of hype, we needed to try it for ourselves. We got the unflavored version and made DIY protein shakes, protein pancakes, and even protein soups. In this Isopure protein review, we’ll share our experience, highlighting the good and the not-so-good—plus share the results of our proprietary lab testing on this protein powder—to help you decide if it’s right for your protein needs.

Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider. GGR also recommends choosing a product that has been third-party tested for quality.

We’ve Tried a Lot of Protein

Our testers have personally tasted more than 70 protein powders, two dozen pre-made protein shakes, and a dozen meal replacement shakes. All this to say, we’ve had a lot of firsthand experience with most of the popular protein supplements out there—and we have a lot to say about them.

We developed an extensive rating system for supplements, and, as part of our GGR supplement testing methodology for protein powder, we dug into various factors, including taste, solubility, price, and third-party testing (among other things), and meticulously recorded our experience. We try protein powders with plain water, mix them with other ingredients in smoothies, and stir them into savory foods to see how they affect the taste. Then, we pass on all our findings to you.

Oh, and did we mention our team is made up of certified personal trainers, certified nutrition coaches, professional athletes, and certified CrossFit coaches? In other words, we’re not just interested in health and fitness; we live it. 

Isopure Whey Protein Isolate

Isopure Whey Protein Isolate

GGR Score: 4.2 starstarstarstarstar

Product Highlights

  • 100% unflavored whey protein isolate
  • 25 g of protein
  • Zero carbohydrates and fats
  • Sugar-free and lactose-free
  • Available in 16 servings or 47 servings

Pros & Cons

Pros

  • Pure whey isolate
  • Sugar-free
  • Lactose-free

Cons

  • Only unflavored available
  • Reviews report odd taste especially when mixed in water

Bottom Line

If you’re looking for a pure whey protein isolate, a great option is Isopure Unflavored Whey Protein Isolate. This isolate is 100% whey with no carbohydrates and fats, making it sugar-free and lactose-free. This protein powder is available in 16 servings or 47 servings.

A Quick Look at Isopure Whey Protein Isolate

Isopure was launched in 1998 by two men named Hal and Ernie. They made the first batches of protein powder in a cement mixer and now, 25 years later, they have a full lineup of protein powders, protein drinks, and creatine.

RELATED: Best Protein Shakes

The Isopure Whey Protein Isolate is their flagship protein powder. Now there’s also the Isopure Low Carb (a naturally sweetened version with 2 grams of carbohydrates per serving), Isopure Infusions (lighter, fruit-flavored protein powders that are good for mixing with water), and Isopure Plant (a vegan protein powder made with organic pea and brown rice protein).

woman-holding-isopure-protein-whey

We tested the unflavored version of the Isopure zero-carb protein powder; however, for this review, we’ll do our due diligence and highlight some of the nutrition facts for the flavored versions, too.

Before You Buy

  • You’ll get 25 grams of protein per serving, with zero carbs in the unflavored version.
  • It comes in 16- and 47-serving containers, but if you opt for the bigger size, it drops the price per serving pretty significantly.
  • The unflavored version only has two ingredients, but the vanilla and chocolate flavors are fairly “clean” too.
  • This protein powder isn’t third-party tested, which gives us some pause, but Isopure has a good long-standing reputation.

Is Isopure Protein Worth It?

Ultimately, we think the Isopure Protein is a great option for many people. It has a high-quality protein source, tastes good, mixes well with sweet and savory foods (if you get the unflavored version), and is fairly reasonably priced. 

RELATED: Protein Smoothie Recipes

Here’s more information about who we think this protein is great for and who we think might want to skip it.

Great for:

  • Anyone who wants a super clean, pure protein
  • Those on low-carb or keto diets
  • People who want a good, unflavored option to mix into everything

Not recommended for:

  • Shoppers on a budget
  • Those who would rather have a plant-based protein
  • Anyone allergic to soy

Isopure Protein Specs

Price per serving$1.70 to $2.12
FlavorsUnflavored, Chocolate, Vanilla
Protein per serving25 grams
SweetenersNone
Third-party testedNo

Experience Using Isopure Protein

Our tester, GGR Social Media Manager Brittany Combs, tried the unflavored Isopure Whey Protein Isolate and was pleasantly surprised. The take-home message?

“This is a really good unflavored protein powder!” she says.

But here’s some more detailed information on formulation, taste, solubility, and side effects based on her first-hand testing.  

Price Per Serving

Brittany gave the Isopure protein powder a 3 out of 5 rating for price because it’s on the higher end of the spectrum for a protein powder.The price per serving depends on which size you get. If you opt for the smaller, 16-serving size, you’ll pay $2.12 per serving. If you opt for the bulk jar (47 servings), the price drops to $1.70 per serving.

But you should consider that this is a higher quality protein and doesn’t contain artificial ingredients or sweeteners, which you can typically expect to pay more for.

Formulation

The ingredient list is super clean, so Brittany gave Isopure a 5 out of 5 for formulation. The unflavored version she tested has just two ingredients: whey protein isolate and soy lecithin.

isopure-protein-whey-unflavored-Back

There are two flavored versions—Chocolate and Vanilla—and the ingredient list is a little more extensive. Still, it’s much cleaner than many other similar protein powders. The flavored protein powders are made without artificial colors, flavors, or sweeteners and have no unnecessary additives or fillers. They’re also enhanced with vitamin and mineral blends that include vitamins A, C, B12, calcium, potassium, and magnesium.

Taste and Solubility 

The TL;DR is that this protein powder earned a perfect score (5 out of 5) for both taste and solubility. 

“This is actually really good! I have added this to several different foods, and while the texture may have been altered slightly, I never really noticed a change in flavor, which is great! It dissolves well, too,” Brittany says.

RELATED: Best-Tasting Protein Powder

She adds that she and her husband often joke about whether soup is a meal, an appetizer, or a side. In her opinion, “If it’s got protein, it’s a meal,” so she adds this unflavored protein to their soups, and “you can’t even tell.”

woman-holding-isopure-protein-whey-unflavored-pancake-mix

She also mixes it into pancakes for her kids, and they don’t notice a difference either. Another huge win if your kids are picky eaters, as this turns a morning standard that would be mostly carbs and sugar into a high-protein breakfast without altering the taste or texture.

Side Effects

Brittany (and her family) didn’t experience any side effects when testing this protein powder, and isolates are pretty well-tolerated in general. 

During processing, whey isolates have most of the fat and lactose removed. Because of this, even people with lactose intolerance can usually take them without an issue1. That said, whey protein powders can cause digestive upset2 in some people, so if you’re new to whey protein, you might want to start small and work your way up to a full serving over a couple weeks. Or try one of our recommendations for the best protein powders for sensitive stomachs.

Third-Party Testing 

Isopure isn’t very forthcoming about third-party testing on their website. After messaging the company directly, we found that the products actually aren’t third-party tested, which does give us some pause.

They said that products are tested during the manufacturing process by their own quality team, and that raw materials are tested to ensure the supplier information is accurate. They also stated they only source from suppliers that go through rigorous certification processes, and all raw materials are tested for identity, purity, strength and composition as required by FDA CFR 21 Part 111 for Dietary Supplements3.

However, GGR conducted its own third-party testing with independent, accredited lab Ellipse Analytics. We tested more than 150 protein powders for label accuracy and purity, and Isopure Zero Carb protein in the Unflavored option received Excellent ratings all around; this means that it fell in the top 10% of all products we tested for heavy metals and protein content.

Scorecard for third-party lab testing of Isopure zero carb unflavored protein
GGR collaborated with Ellipse Analytics, an accredited third-party lab, to test more than 150 protein powders. We screened for dozens of factors and rated each product against its peers. Excellent indicates the top 10% of products; Above Average is the top 25% of products; and Meets Standard is the top 50%.

Our Independent Supplement Testing Glossary explains in more detail what all of these purity criteria mean. It’s important to note that even if one of these contaminants has been detected in a product, it doesn’t mean that the protein powder is immediately harmful. It can, however, be harmful over time and with repeated exposure, so third-party testing can help people mitigate personal risk.

Comparison to Similar Products: Isopure Protein vs Optimum Nutrition 

Optimum Nutrition Gold Standard Whey

Optimum Nutrition Gold Standard 100% Whey

GGR Score: 4.2 starstarstarstarstar

Product Highlights

  • Contains 3 different kinds of whey protein
  • Tested for banned substances
  • Over 5 g of BCAAs per serving
  • Instantized to help prevent clumping

Pros & Cons

Pros

  • Affordable
  • High in protein
  • Plenty of flavor options
  • Low in carbs

Cons

  • Some users say it's overly sweet
  • Contains artificial flavors
  • Most flavors contain sucralose

Bottom Line

Optimum Nutrition Gold Standard 100% Whey is a team favorite for its budget-friendly prices and taste. Our team has tried multiple Optimum Nutrition flavors, and every one is ranked a 4 or 5 out of 5.

Optimum Nutrition Gold Standard Whey, or “ON Gold Standard Whey,” as the fitness enthusiasts call it, is one of the most popular budget-friendly whey protein supplements. Aside from the price per serving, one of the biggest differences from Isopure is the ingredient list.

Isopure uses only natural ingredients and no artificial sweeteners; ON relies on both natural and artificial fillers, and sweetens its protein powders with artificial sweeteners like sucralose. The ON protein also contains a blend of whey protein isolate and whey protein concentrate, so it’s not lactose-free like the Isopure.

For a more in-depth analysis of ON Gold Standard Whey, check out our Optimum Nutrition 100% Whey Gold Standard review.

Here’s a side-by-side breakdown of both protein powders.

Isopure Whey Protein IsolateOptimum Nutrition Gold Standard Whey
Price per serving$1.70 to $2.12$1.18 to $1.55
FlavorsUnflavored, Chocolate, Vanilla18 flavors; made with
natural and artificial flavors 
Protein per serving25 grams24 grams
SweetenersNone (unflavored); cane sugar
and monk fruit (flavored)
Sucralose
Third-party tested?NoYes; Informed Choice

Customer Experience 

Isopure’s return policy is straightforward. You can return your purchases directly through the brand’s website within 30 days of receiving your shipment. Returns won’t be accepted past 30 days. 

There’s no money-back guarantee like with some other protein powders, though. You can’t return an opened protein powder, so if you don’t like it, you’re stuck with it.

Ordering Isopure Whey Protein Isolate

When you order this protein from the brand, you can choose from two size options: 16 or 47 servings. There’s no subscription option, but you can get 15% off your first order if you sign up for Isopure’s newsletter. You’ll also get free standard delivery if you spend $75 or more. If you spend less than that, shipping is just under $6 for standard delivery (3 to 8 days) or $17 for next-day. 

isopure-protein-whey-unflavored-powder-open-bag

Customer Reviews

Isopure’s Whey Protein Isolate has almost 10,000 customer reviews on Amazon, most of which are overwhelmingly positive. 

The protein powder has an average of 4.5 out of 5 stars, and customers call out the clean ingredient list, excellent solubility, and lack of side effects as some of the best features of the protein powder. Several reviewers say they don’t even need to use a blender—they just mix it with a shaker cup or even a spoon and it mixes perfectly. 

“It works well for mixing in with lots of different flavors. I actually got this to mix with coconut water to get the benefits of that plus protein post-workout. Tastes like it’s not even there, dissolves easily and has a good protein content with low carbs,” writes one Amazon reviewer.

Ketogenic reviewers also love that the unflavored version has zero carbs and a high protein content.

“[It’s] so great for making my keto baked goods! I make keto bread and keto cakes with it, and even a tempura batter with it this year for Christmas! Versatile is an understatement. I strive to always have this product in my cabinet, and you cannot beat this price anywhere you look,” says one five-star reviewer.

RELATED: Best Keto Protein Powder

Final Verdict of Our Isopure Whey Protein Isolate Review

isopure-protein-whey-unflavored-powder-scoop

Overall, we really like the Isopure Whey Protein Isolate. It tastes good and blends in well, and the macronutrient profile is really impressive, especially for those on high-protein and/or low-carb diets. The downside is that it’s not third-party tested, so you’ll have to take the brand’s word that you’re getting what they say you are.

  • It’s a high-quality, low-carb protein
  • It tastes good and blends/dissolves well
  • No third-party testing to back up claims

If you want to see what else the team of experts at GGR recommends, check out our roundup of the best whey protein.

Full Rating

Isopure Whey Protein Isolate

Isopure Unflavored Whey Protein Isolate is 100% whey with no carbohydrates and fats, making it sugar-free and lactose-free. This protein powder is available in 16 servings or 47 servings.

Product Brand: Isopure

Product Currency: USD

Product Price: 27.50

Product In-Stock: InStock

Editor's Rating:
4.2

Isopure Whey Protein Isolate Rating

Price per serving – 3
Formulation – 5
Taste – 5
Solubility – 5
Side effects – 5
Third-party testing – 3
Customer service – 3
Customer reviews – 4.4

Isopure Whey Protein Isolate: FAQs

Does Isopure protein build muscle?

Yes, Isopure protein may help you build muscle when combined with regular strength training. This isn’t exclusive to the Isopure brand, though, as all whey protein supplements may contribute to muscle-building4.

Is Isopure a clean protein powder?

On the surface, Isopure makes a very clean protein powder. There are only two ingredients for the unflavored version, and it’s an isolate, which means most of the fat and lactose are removed, leaving you with a very pure protein. There is a gray area, though. Isopure’s products aren’t third-party tested, so there’s no way to verify exactly what’s in them.

What happens when you take Isopure whey protein?

In the short term, Isopure protein powder can help curb cravings and reduce appetite5, so you may consume fewer calories, which can contribute to weight loss (if that’s your goal). In the long-term, it can help you build lean muscle mass6 when combined with strength training. Whey protein is also high in L-glutamine, which is connected to better gut health7.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

References

1. Hoffman, JR, Falvo, MJ. Protein – which is best?. J Sports Sci Med. 2004;3(3):118-130. 

2. Ambulkar, P, Hande, P, Tambe, B, et al. Efficacy and safety assessment of protein supplement – micronutrient fortification in promoting health and wellbeing in healthy adults – a randomized placebo-controlled trial. Transl Clin Pharmacol. 2023;31(1):13-27. doi:10.12793/tcp.2023.31.e1

3. U.S. Food and Drug Administration. Small entity compliance guide: current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. December 2010.

4. Kim, CB, Park, JH, Park, HS, Kim, HJ, Park, JJ. Effects of whey protein supplement on 4-week resistance exercise-induced improvements in muscle mass and isokinetic muscular function under dietary control. Nutrients. 2023;15(4):1003. doi:10.3390/nu15041003

5. Rigamonti, AE, Leoncini, R, De Col, A, et al. The appetite-suppressant and GLP-1-stimulating effects of whey proteins in obese subjects are associated with increased circulating levels of specific amino acids. Nutrients. 2020;12(3):775. doi:10.3390/nu12030775

6. Bergia, RE 3rd, Hudson, JL, Campbell, WW. Effect of whey protein supplementation on body composition changes in women: a systematic review and meta-analysis. Nutr Rev. 2018;76(7):539-551. doi:10.1093/nutrit/nuy017

7. Perna S, Alalwan TA, Alaali Z, et al. The role of glutamine in the complex interaction between gut microbiota and health: a narrative review. Int J Mol Sci. 2019;20(20):5232. doi:10.3390/ijms20205232

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